A blog about dermatology and its related topics. Guide to cope up with dermatology disorders and some dermatology treatments.
Recognition of the vesiculobullous diseases is usually not difficult. Specifically, cutaneous lesions containing any number of intact, clear, fluid-filled blisters should be assigned to this group. Problems can arise if, in a blistering process, all the roofs have been broken. In this situation the presence of perfectly round erosions with a thin collarette of scale […]
Diagnostic Hallmarks
Distribution - tips and sides of the digits, palms and soles
Clustering of minute, noninflammatory vesicles
History of recurrent episodes
Clinical Presentation
Dyshidrosis consists of minute, noninflammatory vesicles located along the lateral sides and tips of the digits. Individual vesicles are rarely more than 1 mm in diameter, but as the disease increases in severity, tight clustering […]
Diagnostic Hallmarks
Distribution: often starts on the extremities but becomes generalized fairly quickly
Tense, tough blisters usually arising from normal skin
Individual lesions heal spontaneously while new blisters continue to appear
Immunofluorescent studies: IgG and C3 in a linear pattern at the dermal-epidermal junction.
Clinical Presentation
Patients with pemphigoid characteristically develop the disease after the age of 60. Crops of large […]
Diagnostic Hallmarks
Distribution: trunk, palms, soles, lips, and other mucous membranes
Tense blisters arising from the center of an erythematous base
Presence of some target-type lesions
Clinical Presentation
Most patients with erythema multiforme do not develop bullous lesions . When blisters do occur, they are present from the onset of the illness and usually are a harbinger of a rather […]
Diagnostic Hallmarks
Distribution - elbows, knees, sacrum, and scapular areas
Herpetic-like clustering of vesicles
Immunofluorescent biopsy studies: granular deposits of immunoglobulin A (IgA) in the papillary dermis
Rapid response to dapsone therapy
Clinical Presentation
As its name “herpetiform” implies, the very uncommon condition, dermatitis herpetiformis, is characterized by the presence of clustered, small vesicles. The individual vesicles are usually […]
Diagnostic hallmarks
Distribution - perioral, genital, and perigenital skin
Tight clustering of small vesicles
Recurrent episodes in the same location
Clinical Presentation
Cutaneous infection with Herpesvirus hominis (HSV 1 and HSV 2) results in the appearance of small vesicles of uniform size and shape. Two clinical patterns are commonly seen, herpes labialis and herpes genitalis.
Herpies labialis consists of […]
Diagnostic Hallmarks
Distribution: plantar aspect, especially instep, of the foot
Associated fungal infection of the toenails and web space
Positive potassium hydroxide (KOH) preparation from vesicle roof
Clinical Presentation
Fungal infections can occur anywhere on the body, but blister formation as a component of fungal infection occurs only on the plantar surfaces of the feet. The vesicles of […]
Diagnostic Hallmarks
Distribution: exposed areas, unilateral or asymmetrical location
History of specific trauma
Clinical Presentation
Traumatic bullae occur as a result of friction, thermal burns, or long-term constant pressure (”coma blisters”). A history of friction or burn is ordinarily apparent, but this history may not be given in cases of child abuse. Likewise, a useful, spontaneously given history […]